Héctor Corrada Bravo bio photo

Héctor Corrada Bravo

Senior Scientist
Research and Early Development
Genentech


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Methods for analysis of DNA methylation from second-generation sequencing and microarrays.
  • Dorri, F., Mendelowitz, L., Corrada Bravo, H. (2015). “methylFlow: cell-specific methylation pattern reconstruction from high-throughput bisulfite-converted DNA sequencing”. HitSeq 2015. Bioinformatics

  • Hansen, K. D., Timp, W., Corrada Bravo, H., Sabunciyan, S., Langmead, B., McDonald, O. G., Wen, B., et al. (2011). “Increased methylation variation in epigenetic domains across cancer types.” Nature Genetics, 43(8), 768–775. Nat. Genetics

  • W. Timp, H. Corrada Bravo, O.G. McDonald, M. Goggins, C. Umbricht, M. Zeiger, A.P. Feinberg, R.A. Irizarry (2014). Large hypomethylated blocks related to large heterochromatin regions as a universal defining epigenetic alteration in human solid tumors. Genome Medicine, in press. Genome Medicine

  • M. Aryee, A. Jaffe, H. Corrada Bravo, C. Ladd-Acosta, A. Feinberg, K. Hansen, RA. Irizarry (2014). Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA Methylation microarrays. Bioinformatics, 30 (10), 1363-9. Bioinformatics

  • methylFlow Github Repo

  • minfi Bioconductor package

  • bumphunter Bioconductor package