Héctor Corrada Bravo bio photo

Héctor Corrada Bravo

Associate Professor
Center for Bioinformatics and Computational Biology
Computer Science
Univ. of Maryland

Mailing Address:

8314 Paint Branch Dr. #3114F
College Park, MD 20742

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Simple models of intensity measurements in second-generation sequencing data give easily interpretable quality assessment metrics while capturing uncertainty in base-calling and mapping. Applications to variant calling in pooled resequencing experiments.
  • Okrah, K. and Corrada Bravo, H. (2015). “Shape analysis of high-throughput transcriptomics experiment data”. Biostatistics doi: 10.1093/biostatistics/kxv018. Biostatistics

  • H. Corrada Bravo, R.A. Irizarry. “Model-based quality assessment and base-calling for second-generation sequencing data” (Novmeber 2009). Biometrics Published online before print, Novemeber 13,
    1. doi10.1111/j.1541-0420.2009.01353.x Biometrics
  • Wu, H., Irizarry, R. A., Bravo, H. C. (2010). “Intensity normalization improves color calling in SOLiD sequencing.” Nature method, 7(5), 336–337. Nat. Methods

  • Niranjan, T. S., Adamczyk, A., Bravo, H.C, Taub, M. A., Wheelan, S. J., Irizarry, R., & Wang, T. (2011). “Effective detection of rare variants in pooled DNA samples using Cross-pool tailcurve analysis”. Genome Biology, 12(9), R93. Genome Biology

  • C. Ye, C. Hsiao, H. Corrada Bravo. BlindCall: ultra-fast base-calling of second-generation sequencing by blind deconvolution (2014). Bioinformatics, 30 (9), 1214-9. Bioinformatics